Does Fasting make you fat?
            by Brad Pilon

If I remember correctly, the FTC views the use of animal research in supplement advertising to be one of the most heinous advertising infractions, right up there with Photoshopped before and after photos.

Why?

Because they believed that due to the lack of transferability of animal research to humans, doing so would be intentionally misleading the customer as to the potential benefits of said supplement.

Even the most ‘fly-by-night’ ethically-devoid supplement companies do not use animal trials in their marketing for this reason.

Keep this in mind when you see journalists and bloggers reporting on the latest mouse research, using it to create clickbait style articles about human diet, nutrition and weight loss.

Alright, now that I’ve said that, lets get to that article that appeared on Yahoo suggesting that skipping meals will actually make you fatter.

It was an animal study, using mice.

We know that mice are extremely sensitive to fluctuations in both body weight and meal patterns. They are very small animals, and without getting too technical I’ll just say it’s well known in the scientific community that many parts of metabolism scale with size.

For 5 days the mice in the diet group were given half the amount of food as the control mice, and all of the food was provided in one meal per day (that’s why it’s being referred to as a ‘fasting study’).

After 5 days of dieting the mice were allowed to gorge for 13 days, they were given an amount of food that was the same or more as the control mice, and were still only eating it all in one meal.

So what happened?

The control mice continue to grow normally, and their weight increased throughout the study, but the fasting diet-restricted mice lost almost 20% of their body weight in the first 5 days of the study. (This should be your first hint that mice are different than humans. If you and I eat 50% of our daily intake for 5 days we’re not going to lose 20% of our body weight – heck, we could do this for a month and we’re probably not losing 20% of our body weight.)

Then, the fasted mice were fed 98-122% of the amount of food as the growing control mice, so the fasted mice started to grow… and they grew quickly. If you think about it, they were getting fed the same amount of food (or more) as the mice that were 30% heavier then them… so rapid weight gain (and fat gain) make sense.

So end result? Mice who rapidly lost 20% of their body weight and then regained most of that weight by overeating ended up with larger fat cells then the control mice. I’m not sure why this is surprising.

They also had worse measurements of a bunch of health markers… again not surprising.

I’m not sure how much the eating cycle mattered here. Again, as I stated earlier, mice are really sensitive to eating patterns so it probably did play some sort of role, but rapid weight loss then overfeeding causing increased fat stores and messed up glucose control isn’t surprising.

My own lifetime of observation and personal experience tells me that the following article is “The Real Deal” on the issue of maintenance of a large weight-loss - including long-term maintenance. 

By “The Real Deal”,  I mean genuine, authentic, true, exact, trustworthy, and clear.

For those who don’t know, for the past 10+ years I’ve been successfully struggling to maintain my 5 ft 0 inch elderly body at a “normal” BMI after years of “morbid obesity”, through a great many different dieting methods.  More information is in  ABOUT ME as well as in many articles about my Status in the ARCHIVES.  I will be writing more about my personal weight and calorie details at the bottom of the following article:


You Should Never Diet Again:
The Science and Genetics of Weight Loss

To maintain a new weight,
you have to fight evolution.
You have to fight biology.
And you have to fight your brain

         by Dr. Traci Mann  .. Excerpted from "Secrets From the Eating Lab". (2015)


I’ve given you the bad news: diets fail in the long run. Now, let’s try to understand why.

In social psychology we often say that if you find that most people behave in the same way, then the explanation for their behavior has very little to do with the kind of people they are. It has to do with the circumstances in which they find themselves. For example, most students in class raise their hands and wait quietly to be called on before speaking. It’s not that they are all timid or overly polite types of people. It’s that the classroom setting is sufficiently powerful that without really thinking about it, nearly everyone ends up following the same unwritten rules. When we think about people who regain weight after dieting, it’s a similar principle. It’s not that they have a weak will or lack discipline, or that they didn’t want it enough, or didn’t care. It’s about the circumstances in which they find themselves, and the automatic behavior that is provoked by those settings. In other words: if you have trouble keeping weight off, it is not a character flaw.

When it comes to keeping weight off, a combination of circumstances conspires against you. Each one on its own makes it difficult, but put them together and you are no longer in a fair fight. One circumstance that makes things hard is our environment of near-constant temptation. Two others are biology and psychology. I realize it may seem odd to you that I am calling these things “circumstances,” but, like...

There is a “widespread misimpression” that weight-loss and maintenance for bodies which have become and stayed obese for more than a couple of years, is essentially the same as that for bodies which always have been:

• normal weight (BMI between 18.5-24.9);
• overweight (BMI between 25-29.9); or
  
• have spent a brief time within Grade 1 obesity (BMI between 30-34.9).
  
  

In a commentary published February 26, 2015 in the journal Lancet Diabetes and Endocrinology, four weight-loss specialists set out to correct what they view as the widespread misimpression that people who have become and stayed obese for more than a couple of years can, by diet and exercise alone, return to a normal, healthy weight and stay that way.

"Once obesity is established, however, body weight seems to become biologically 'stamped in' and defended," wrote Mt. Sinai Hospital weight management expert Christopher N. Ochner and colleagues from the medical faculties of the University of Colorado, Northwestern University and the University of Pennsylvania.  

“Few individuals ever truly recover from obesity.” Those that do "still have 'obesity in remission,' and are biologically very different from individuals of the same age, sex and body weight who never had obesity." They are constantly at war with their bodies' efforts to return to their highest sustained weight.

That February 2015 commentary together with the August 2013 research article below explain many of the things that I have experienced personally, and that I have personally observed.

An additional article dealing with this issue is located HERE in the DietHobby Archives.

Biological Mechanisms that Promote Weight Regain Following Weight Loss in Obese Humans
          by Christopher N. Ochner; Dulce M. Barrios; Clement D. Lee; F. Xavier Pi-Sunyer
                     Published August 2013

Abstract

Weight loss dieting remains the treatment of choice for the vast majority of obese individuals, despite the limited long-term success of ...

We all have choices on how we are going to live our lives, and where we are going to place our focus.  My choice may not resemble your choice. I am a “reduced obese” person who has maintained a “normal” weight for more than 9 years, after a lifetime of Yo You Dieting. See ABOUT ME for details.

Doing this has required my constant vigilance, ongoing effort, and tremendous focus, and even though I have been more successful than 95% of everyone who has ever accomplished a large weight-loss, it is been a tremendous personal struggle, and year-after-year, despite CONSISTENT and CONSTANT effort, my weight has continued to slowly creep upward in small increments over time.

This is despite the fact that the recorded daily calorie average of my food intake has been dropping lower and lower each year.

For example, at the start of 2015, my weight was the same as it was at the start of 2014, however, the average daily calories of all of my daily food intake during the year of 2014 was only 754 calories.

In 2013, the average daily calories of all of my daily food intake was 1033. So my average daily food intake was about 280 daily calories LESS than the prior year, and during that prior year, from the start of 2013 until the start of 2014, my body gained 8 pounds while eating that 1033 calories per day.

These are my personal facts, based on numbers which I recorded as accurately as humanly possible, every single day for the past 10 years. For years I felt like Garfield in the cartoon below, but now... instead of yelling "Liar" at the scale, I mentally yell "Liar" or "You Idiot" at the 'Diet Experts' who smugly believe the B.S. and provide to us the results of bad Research, while asserting that "Science Doesn't Lie".

NOTE: that I am a 5’0” tall, 70 year old, sedentary woman with a lower than average metabolism, and according to the Mifflin formula, the AVERAGE woman with my numbers requires only 1237 daily calories to maintain her current weight.

I give you this information so you can see that my recorded calorie numbers are not as far out in left field as some of you might first suppose. You can’t accurately compare my body’s numbers with your own body’s personal calorie calculation requirements if you are larger, taller, younger, more active etc. ...

The fat burning process is a complex biochemical process.

When you “lose” body fat, the fat cell (also called an adipocyte) does not go anywhere or “move into the muscle cell to be burned”. The fat cell itself, (unfortunately) stays right where it was – under the skin in your thighs, stomach, hips, arms, etc., and on top of the muscles – which is why you can’t see muscle “definition” when your body fat is high.

Fat is stored inside the fat cell in the form of triaglycerol. The fat is not burned right there in the fat cell, it must be liberated from the fat cell through somewhat complex hormonal/enzymatic pathways. When stimulated to do so, the fat cell simply releases its contents (triaglycerol) into the bloodstream as free fatty acids (FFA’s), and they are transported through the blood to the tissues where the energy is needed.

A typical young male adult stores about 60,000 to 100,000 calories of energy in body fat cells. What triggers the release of all these stored fatty acids from the fat cell? When your body needs energy because you’re consuming fewer calories than you are burning (an energy deficit), then your body releases hormones and enzymes that signal your fat cells to release your fat reserves instead of keeping them in storage.

For stored fat to be liberated from the fat cell, hydrolysis (lipolysis or fat breakdown), splits the molecule of triaglycerol into glycerol and three fatty acids. An important enzyme called hormone sensitive lipase (HSL) is the catalyst for this reaction. The stored fat (energy) gets released into the bloodstream as FFA’s and they are shuttled off to the muscles where the energy is needed. As blood flow increases to the active muscles, more FFA’s are delivered to the muscles that need them.

An important enzyme called lipoprotein lipase (LPL), then helps the FFA’s get inside the mitochondria of the muscle cell, where the FFA’s can be burned for energy. If you’ve ever taken a biology class, then you’ve probably heard of the mitochondria. This is the “cellular powerhouse” where energy production takes place and this is where the FFA’s go to be burned for energy.

When the FFA’s are released from the fat cell, the fat cell shrinks and that’s why you look leaner when you lose body fat – because the fat cell is now smaller. A small or “empty” fat cell is what you’re after ...